Is Paget's disease fatal?
Over time, enlarged or misshapen bones can stress nearby joints leading to osteoarthritis in those joints. In very rare cases, Paget's can turn into a life-threatening cancerous bone disease. Severe Paget's disease may cause damage to the heart. via
What is the survival rate for Paget disease?
The 5-year survival rate for a patient with Paget disease and sarcoma is 5-7.5%; however, it may be as high as 50% for those who undergo operative tumor ablation and chemotherapy before metastases occur. The 5-year survival rate for elderly patients with primary nonpagetic sarcoma is 37%. via
Is Paget's disease serious?
Paget's disease of bone can sometimes lead to further, potentially serious problems. These include: fragile bones that break more easily than normal. enlarged or misshapen bones. via
How long can you live with Paget's disease of the breast?
The five-year survival rate for patients with both Paget's disease of the breast and invasive cancer in the same breast is 95.8 percent if it's caught at stage 1. Stage 2 patients have a 77.7 percent survival rate. That rate drops to 46.3 percent in stage 3 and 14.3 percent in stage 4. via
How long does it take for Paget's disease to progress?
The initial skin changes of Paget's disease of the breast may appear relatively benign and many individuals may overlook such symptoms, mistakenly attributing them to an inflammatory skin condition or infection. As a result, diagnosis may be delayed, often up to six months or more. via
Does Paget's disease make you tired?
When Paget's disease is active in several bones, overactive osteoclasts may release enough calcium from the bone as they break it down to cause an elevated calcium level in the blood. This rare complication can lead to a number of symptoms, including: Fatigue. via
What are the stages of Paget disease?
Three phases of Paget disease have been described: lytic, mixed lytic and blastic, and sclerotic. In an individual patient, different skeletal lesions may progress at different rates. Thus, at any one time, multiple stages of the disease may be demonstrated in different skeletal regions. via
What Paget's disease looks like?
Paget's disease of the nipple always starts in the nipple and may extend to the areola. It appears as a red, scaly rash on the skin of the nipple and areola. The affected skin is often sore and inflamed, and it can be itchy or cause a burning sensation. The nipple can sometimes be ulcerated. via
What is the most common age to be diagnosed with Paget's disease?
Age. People older than 50 are most likely to develop the disease. Sex. Men are more commonly affected than are women. via
Is Pagets disease curable?
There's currently no cure for Paget's disease of bone, but treatment can help relieve the symptoms. If you do not have any symptoms, your doctor may suggest keeping an eye on your condition and delaying treatment until any problems occur. via
How does Paget's disease start?
Doctors don't know what causes Paget's disease of the breast. The most widely accepted theory is that the disease results from an underlying ductal breast cancer. The cancer cells from the original tumor then travel through milk ducts to the nipple and its surrounding skin. via
Does Paget's disease run in families?
Mutations in the SQSTM1 gene are the most common genetic cause of classic Paget disease of bone, accounting for 10 to 50 percent of cases that run in families and 5 to 30 percent of cases in which there is no family history of the disease. via
What is the first line treatment for Paget disease?
Bisphosphonates are first-line therapy for Paget's disease, and the advent of the new bisphosphonates permits a dramatic improvement in treatment. via
Is Paget's disease genetic?
The cause of Paget's disease is unknown but involves genetic factors. Familial cases display an autosomal dominant pattern of inheritance with incomplete penetrance. Genetic heterogeneity has been demonstrated and eight potential susceptibility loci identified. via